RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity
نویسندگان
چکیده
منابع مشابه
RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity
We have ablated the cellular RNA degradation machinery in differentiated B cells and pluripotent embryonic stem cells (ESCs) by conditional mutagenesis of core (Exosc3) and nuclear RNase (Exosc10) components of RNA exosome and identified a vast number of long non-coding RNAs (lncRNAs) and enhancer RNAs (eRNAs) with emergent functionality. Unexpectedly, eRNA-expressing regions accumulate R-loop ...
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ژورنال
عنوان ژورنال: Cell
سال: 2015
ISSN: 0092-8674
DOI: 10.1016/j.cell.2015.04.034